Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5

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Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5

Depression of electrocorticogram propagating over the cortex surface results in cortical spreading depression (CSD), which is probably related to the pathophysiology of stroke, epilepsy, and migraine. However, preconditioning with CSD produces neuroprotection to subsequent ischemic episodes. Such effects require the expression or activation of several genes, including neuroprotective ones. Rece...

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ژورنال

عنوان ژورنال: Neuropsychiatric Disease and Treatment

سال: 2016

ISSN: 1178-2021

DOI: 10.2147/ndt.s107074